Niacinamide

ナイアシンアミド

Also known as: Vitamin B3, nicotinamide

Brightening (美白) quasi-drug strong evidence

What It Does

A versatile ingredient that brightens, strengthens the skin barrier, controls oil, and minimizes pores. Works well with almost everything.

Niacinamide, also known as vitamin B3 or nicotinamide, is one of the most versatile and well-tolerated active ingredients in skincare. It brightens, strengthens the skin barrier, controls oil, minimizes pores, and has anti-inflammatory properties. This multifunctional nature makes it a staple in both Japanese and global skincare formulations.

Unlike ingredients that block melanin production, niacinamide works by inhibiting melanosome transfer from melanocytes to keratinocytes. This means it stops pigment from spreading through the skin rather than preventing its creation. It also strengthens the ceramide barrier, regulates sebum production, and stimulates collagen synthesis.

In Japan, niacinamide recently gained expanded quasi-drug approval. It was already approved for brightening, but in 2018 it became one of the few ingredients approved for wrinkle improvement claims as well. This dual approval makes it uniquely valuable in the Japanese market. You will find it in everything from affordable drugstore serums to high end treatments, typically at concentrations of 2 to 10 percent.

How It Works

Inhibits melanosome transfer from melanocytes to keratinocytes, preventing pigment spread. Strengthens ceramide barrier, regulates sebum, stimulates collagen, and reduces inflammation.

The Japanese Context

Holds dual quasi-drug approval in Japan for both brightening and wrinkle improvement. One of the few ingredients with multiple approved efficacy claims.

Best For

all skinoily skinsensitive skin dark spots uneven tone enlarged pores fine lines redness acne

How It's Used

Typical concentration: 2 to 10%, with 5% being most common

Ingredient Interactions

Side Effects and Cautions

Extremely well tolerated. Rare flushing or redness in high concentrations. Safe for sensitive skin.

Products With Niacinamide

Aqualabel - Antiaging Oil In Treatment Lotion Moist - 170ml
Aqualabel

Aqualabel - Antiaging Oil In Treatment Lotion Moist - 170ml

1 retailer
Aqualabel - Antiaging Oil In Treatment Lotion Rich Moist - 170ml
Aqualabel

Aqualabel - Antiaging Oil In Treatment Lotion Rich Moist - 170ml

1 retailer
Cica Serum Treatment Lotion - 170ml
Aqualabel

Cica Serum Treatment Lotion - 170ml

1 retailer
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Freeplus (Kanebo)

Freeplus Moist Care Lotion

1 retailer
Hada Labo Gokujyun Aging Care Cream
Hada Labo

Hada Labo Gokujyun Aging Care Cream

1 retailer
Hada Labo Gokujyun Aging Care Emulsion
Hada Labo

Hada Labo Gokujyun Aging Care Emulsion

2 retailers
Hada Labo Gokujyun Aging Care Firming Lotion - 170ml
Hada Labo

Hada Labo Gokujyun Aging Care Firming Lotion - 170ml

2 retailers
Hada Labo Gokujyun Aging Care Lotion
Hada Labo

Hada Labo Gokujyun Aging Care Lotion

2 retailers
Hada Labo Gokujyun Wrinkle Care Cream
Hada Labo

Hada Labo Gokujyun Wrinkle Care Cream

2 retailers
Japanese Sake Moisturizing Skincare Lotion - 500ml
Hakutsuru

Japanese Sake Moisturizing Skincare Lotion - 500ml

2 retailers
Kiku-Masamune Sake Moisturizing Cream
Kikumasamune

Kiku-Masamune Sake Moisturizing Cream

5 retailers
Kose Infinity Intensive Wrinkle Serum
Kose

Kose Infinity Intensive Wrinkle Serum

1 retailer
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Matsuyama

Matsuyama Hadauru Moisturizing Infusion Balancing Lotion

1 retailer
Sana Nameraka Honpo Wrinkle Gel Cream N
Sana

Sana Nameraka Honpo Wrinkle Gel Cream N

5 retailers
SANA Wrinkle Turn Concentrate Blemish & Wrinkle Serum
Sana

SANA Wrinkle Turn Concentrate Blemish & Wrinkle Serum

2 retailers
Shiseido Vital Perfection Uplifting and Firming Cream
Shiseido

Shiseido Vital Perfection Uplifting and Firming Cream

10 retailers
SK-II GenOptics Infinite Aura Essence
SK-II

SK-II GenOptics Infinite Aura Essence

6 retailers
Suncut Multi Vitamin UV Essence SPF50+/PA++++
Kose

Suncut Multi Vitamin UV Essence SPF50+/PA++++

3 retailers
SK-II GenOptics Spot Essence
SK-II

SK-II GenOptics Spot Essence

4 retailers
KOSE CoenRich Q10 Whitening Hand Cream
Kose

KOSE CoenRich Q10 Whitening Hand Cream

1 retailer
KOSE CoenRich Whitening Medicated Hand Cream
Kose

KOSE CoenRich Whitening Medicated Hand Cream

1 retailer
SK-II SKINPOWER Advanced Cream
SK-II

SK-II SKINPOWER Advanced Cream

5 retailers
SK-II SKINPOWER Essence
SK-II

SK-II SKINPOWER Essence

5 retailers
SK-II SKINPOWER Advanced Airy Cream
SK-II

SK-II SKINPOWER Advanced Airy Cream

4 retailers
Sana Soy Milk Pure White Lotion
Sana

Sana Soy Milk Pure White Lotion

2 retailers
BCL Momo Puri Niacinamide & Peach Ceramide Water
BCL

BCL Momo Puri Niacinamide & Peach Ceramide Water

1 retailer
Shiseido Benefiance Wrinkle Smoothing Eye Cream
Shiseido

Shiseido Benefiance Wrinkle Smoothing Eye Cream

6 retailers
Shiseido Benefiance Wrinkle Smoothing Cream
Shiseido

Shiseido Benefiance Wrinkle Smoothing Cream

11 retailers
SHISEIDO Essence Skin Setting Powder
Shiseido

SHISEIDO Essence Skin Setting Powder

1 retailer
SK-II Skin Power Advanced Cream
SK-II

SK-II Skin Power Advanced Cream

4 retailers
Momopuri BC Niacinamide Moist Barrier Serum Mask
Momopuri

Momopuri BC Niacinamide Moist Barrier Serum Mask

No retailers yet
Grace One Wrinkle Care White Moist Essence
Grace One

Grace One Wrinkle Care White Moist Essence

1 retailer
Quality 1st Derma Laser Super NMN 100 Mask
Quality 1st

Quality 1st Derma Laser Super NMN 100 Mask

1 retailer
FAS The Black Day Cream SPF50+ PA++++
FAS

FAS The Black Day Cream SPF50+ PA++++

No retailers yet
ORBIS Wrinkle Bright UV Protector SPF50+ PA++++
ORBIS

ORBIS Wrinkle Bright UV Protector SPF50+ PA++++

1 retailer
🧖
Shiseido

Shiseido Benefiance Wrinkle Smoothing Cream Enriched

3 retailers
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Shiseido

Shiseido Vital Perfection Uplifting and Firming Cream Enriched

2 retailers
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Shiseido

Shiseido Vital Perfection LiftDefine Radiance Serum

2 retailers
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Shiseido

Shiseido Vital Perfection Uplifting and Firming Advanced Cream

3 retailers
🧖
Kikumasamune

Kiku-Masamune Sake Lotion Glossy Moist

No retailers yet
Shiseido Men Total Revitalizer Cream
Shiseido

Shiseido Men Total Revitalizer Cream

2 retailers
SK-II SKINPOWER Under Eye Cream
SK-II

SK-II SKINPOWER Under Eye Cream

No retailers yet